PROMETHEUS is an 8-week clinical feasibility study testing a multimodal precision geromedicine protocol that combines lifestyle interventions (sleep, diet, exercise, behavioral therapy) with personalized nutraceutical supplementation including NMN, urolithin A, and multivitamins. Participants are stratified by ‘gerotypes’—individual aging patterns beyond chronological age—with baseline supplementation chosen based on muscle mass, VO2peak, and cognitive performance, and adjusted mid-trial based on individual response. This represents a landmark shift toward tailored, multi-compound interventions for healthspan optimization in middle-aged and older adults, directly validating the precision medicine model that practitioners increasingly demand.
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NMN is included in a personalized, gerotype-stratified protocol; feasibility data may inform how to sequence nutraceuticals alongside lifestyle measures.