This systematic review examined experimental evidence for cognitive benefits of angiotensin IV and angiotensin-(1-7), two components of the renin-angiotensin system, across animal models and in vitro studies. The review synthesized findings from preclinical research demonstrating potential cognitive enhancement mechanisms, though the evidence base consists primarily of animal model and in vitro studies rather than human clinical trials. The evidence level is primarily animal model and in vitro research, with limited human clinical data available.
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Preclinical data supports angiotensin IV and Ang-(1-7) cognitive pathways relevant to Dihexa’s proposed mechanism.