This comprehensive literature review synthesizes preclinical evidence showing NMN improves ovarian health through NAD+ restoration, enhancing mitochondrial function, reducing oxidative stress, and modulating sirtuin activity. Animal studies demonstrate NMN delays ovarian aging, improves oocyte quality, restores hormonal profiles, and shows promise in chemotherapy-induced and age-related ovarian decline. The review identifies significant therapeutic potential for reproductive conditions including premature ovarian insufficiency and PCOS, while highlighting the critical gap between strong animal data and the lack of human clinical trials needed for clinical translation.
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Preclinical data suggests NMN supports oocyte quality and ovarian reserve via NAD+ pathways; human trials are still absent, so counsel patients on evidence limitations.