This preclinical study examined whether NMN improves sleep and circadian rhythms in brain-specific SIRT1 knockout and wild-type mice. Both acute (10-day IP injection) and chronic (2-month oral) NMN treatment failed to improve sleep duration or quality in middle-aged mice. The researchers suggest NMN’s reported clinical benefits for sleep in elderly populations may work indirectly through improvements in muscle function and energy metabolism rather than direct sleep mechanisms.
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NMN did not directly improve sleep in mice; benefits seen clinically may reflect improved muscle and metabolic function rather than central sleep mechanisms.