NMN activates SIRT7 and enhances glutamine metabolism to reverse oxidative stress damage in hair follicle stem cells affected by alopecia areata. The study demonstrates NMN restores cell viability, reduces apoptosis, and promotes hair follicle regeneration both in vitro and in vivo through a specific SIRT7-GLS1 pathway. This identifies a novel mechanism for NMN’s therapeutic potential in autoimmune hair loss, directly relevant to practitioners seeking evidence-based peptide and metabolic interventions.
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NMN may support hair follicle stem cell resilience via SIRT7-GLS1 pathway; preclinical data worth monitoring for alopecia areata protocols.