NMN supplementation significantly enhances the efficacy of CAR-NK cell immunotherapy against ovarian cancer by improving NK cell activation, cytokine production, and cytotoxic capacity while protecting cells from tumor microenvironment-induced oxidative stress. The mechanism involves modulation of phosphorylation cascades and mitochondrial redox homeostasis. In xenograft models, NMN-preconditioned CAR-NK cells achieved superior tumor control and enhanced intratumoral infiltration, positioning NMN as a clinically translatable metabolic adjuvant for improving cancer immunotherapy outcomes.
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NMN preconditioning enhanced CAR-NK cytotoxicity in ovarian cancer xenografts; supports NMN’s role in immune cell metabolic resilience.