Microenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury.

Researchers developed an injectable hydrogel system combining GHK-Cu with carbon dots to treat radiation-induced skin injuries. The smart delivery system releases antioxidants first to combat oxidative stress, then releases GHK-Cu in a sustained manner to promote tissue repair and collagen formation. In vitro and in vivo testing showed the combination effectively accelerated healing of radiation-damaged skin by addressing both the inflammatory and regenerative phases of wound healing. This represents a novel dual-phase approach using GHK-Cu for clinical wound management.

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New research shows GHK-Cu can be engineered into smart delivery systems that provide sustained tissue repair benefits for complex wound healing applications.

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