Researchers developed macrophage membrane-camouflaged liposomes co-delivering NMN and L-arginine to reprogram nitric oxide metabolism in atherosclerosis. In vitro studies showed this approach shifts macrophage function from pro-inflammatory iNOS-driven pathways to protective ones, reducing oxidative stress and foam cell formation. The synergistic delivery system demonstrates how NMN can be leveraged alongside amino acids to modulate immune cell metabolism and reduce atherosclerotic progression markers. This supports the therapeutic rationale for NMN supplementation in metabolic and cardiovascular health protocols.
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NMN may support macrophage metabolic reprogramming, potentially reducing foam cell formation and oxidative stress in cardiovascular contexts.