This case series describes perioperative detection of congenital methemoglobinemia, a rare inherited disorder impairing the reduction of methemoglobin to functional hemoglobin, causing functional hypoxia despite normal oxygen saturation. The article highlights that diagnosis is often delayed or made incidentally due to mild clinical presentation. Methylene blue is the established therapeutic agent for acute methemoglobinemia management, making this relevant to practitioners managing perioperative complications and oxidative stress conditions.
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Perioperative methemoglobinemia may present incidentally; methylene blue remains the key acute intervention when functional hypoxia is suspected.